Nanoengineers invent new biomaterial that more closely mimics human tissue

The new biomaterial was created using a brand spanking new biofabrication platform that Chen is developing under a four-year, $1.5 million grant from the National Institutes of Health. This biofabrication process makes use of light, exactly controlled mirrors as well as a computer projection technique — shined on a solution of new cells & polymers — to build three-dimensional scaffolds with well-defined patterns of any shape for tissue engineering.
A new biomaterial designed for repairing damaged human tissue doesn’t wrinkle up when it is stretched. The invention from nanoengineers at the University of Los angeles, San Diego marks a significant breakthrough in tissue engineering because it more closely mimics the properties of native human tissue. Shaochen Chen, professor in the Department of NanoEngineering at the UC San Diego Jacobs School of Engineering, hopes future tissue patches, which are used to repair damaged heart walls, blood vessels & skin, for example, will be more compatible with native human tissue than the patches available today. His findings were published in a recent issue of the journal Advanced Functional Materials.
Although Chen’s team is focused on generating biological materials, he said the manufacturing expertise could be used to engineer plenty of other forms of materials including metal parts used in ships & spacecraft, for example.
“We are also exploring other opportunities,” said Chen. “It’s a brand spanking new material. I think it is a matter of time before more people will pick up & find applications for it in defense, energy & communications, for example.”
Shape turned out to be essential to the new material’s mechanical property. While most engineered tissue is layered in scaffolds that take the shape of circular or square holes, Chen’s team created new shapes called “reentrant honeycomb” & “cut missing rib.” Both shapes exhibit the property of negative Poisson’s ratio (i.e. not wrinkling when stretched) & maintain this property whether the tissue patch has or multiple layers. layer is double the thickness of a human hair, & the number of layers used in a tissue patch depends on the thickness of the native tissue that doctors are trying to repair. A single layer would not be thick to repair a heart wall or skin tissue, for example. The next phase of research will involve working with the Department of Bioengineering at the Jacobs School of Engineering to make tissue grafts to repair damaged blood vessels.

The new biomaterial was created using a brand spanking new biofabrication platform that Chen is developing under a four-year, $1.5 million grant from the National Institutes of Health. This biofabrication process makes use of light, exactly controlled mirrors as well as a computer projection technique — shined on a solution of new cells & polymers — to build three-dimensional scaffolds with well-defined patterns of any shape for tissue engineering.
A new biomaterial designed for repairing damaged human tissue doesn’t wrinkle up when it is stretched. The invention from nanoengineers at the University of Los angeles, San Diego marks a significant breakthrough in tissue engineering because it more closely mimics the properties of native human tissue. Shaochen Chen, professor in the Department of NanoEngineering at the UC San Diego Jacobs School of Engineering, hopes future tissue patches, which are used to repair damaged heart walls, blood vessels & skin, for example, will be more compatible with native human tissue than the patches available today. His findings were published in a recent issue of the journal Advanced Functional Materials.
Although Chen’s team is focused on generating biological materials, he said the manufacturing expertise could be used to engineer plenty of other forms of materials including metal parts used in ships & spacecraft, for example.
“We are also exploring other opportunities,” said Chen. “It’s a brand spanking new material. I think it is a matter of time before more people will pick up & find applications for it in defense, energy & communications, for example.”
Shape turned out to be essential to the new material’s mechanical property. While most engineered tissue is layered in scaffolds that take the shape of circular or square holes, Chen’s team created new shapes called “reentrant honeycomb” & “cut missing rib.” Both shapes exhibit the property of negative Poisson’s ratio (i.e. not wrinkling when stretched) & maintain this property whether the tissue patch has or multiple layers. layer is double the thickness of a human hair, & the number of layers used in a tissue patch depends on the thickness of the native tissue that doctors are trying to repair. A single layer would not be thick to repair a heart wall or skin tissue, for example. The next phase of research will involve working with the Department of Bioengineering at the Jacobs School of Engineering to make tissue grafts to repair damaged blood v
essels.

Source: University of California – San Diego

Enhanced by Zemanta

Leave a Reply

Name *
Email *
Website